Targeted mpox vaccination is the right move, but readiness varies by state. Success depends on microplanning (who, where, when), cold-chain integrity, and community trust. Health educators should brief religious and traditional leaders ahead of rollout to counter rumours. Set up fixed posts in high-burden LGAs with mobile teams for hard-to-reach wards. Use simple tally sheets and daily dashboards (doses received, administered, wastage, AEFI reports) that LGAs can share publicly. For surveillance, encourage clinics to test rashes instead of assuming “all pox is chickenpox.” Train front-line workers on PPE and case definitions. If states combine good logistics with honest communication (“what we know, what we don’t yet know”), uptake will be decent and spread limited. Panic helps nobody; precision and empathy do.